Molecular Machinery Mediating Vesicle Budding, Docking and Fusion

Cell Structure and Function

James E. Rothman¹  Thomas H. Söllner¹ 

[1] Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center

关键词: vesicle budding and fusion;    ARF;    coat proteins;    cargo receptor;    NSF;    SNAP;    SNARE;   

DOI  :  10.1247/csf.21.407

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(69)Cited-By(13)A general machinery buds and fuses transport vesicles which connect intracellular compartments with each other and allow communication with the extracellular environment. Cytoplasmic coat proteins deform membranes to bud vesicles and interact directly or indirectly with cargo molecules. Compartment-specific SNAREs on vesicles and target membranes dock vesicles and provide a scaffolding for the general fusion machinery to initiate lipid bilayer fusion.

【 授权许可】

Unknown