Intracellular Localization of the HLAClass II Gene Products in Transfected Mouse L Cells

Cell Structure and Function

Takako Nakatsuji¹  Akira Akatsuka² 

[1] Department of Transplantation, Tokai University School of Medicine;Division of Central Electron-microscope, Tokai University School of Medicine

关键词: HLA class II antigen;    morphology;    transfectants;   

DOI  :  10.1247/csf.17.55

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(20)Cited-By(1)To investigate the impaired cell surface expression of humanmajor histocompatibility antigen (HLA) in transfected L cells, we examined their intracellular localization by immunocytochemistry. HLAclass II molecules produced in transfected L cells were mainly detected in the intracellular vesicles and in the nuclear envelope as granular precipitates. The results suggest that the intracellular transport of the newly synthesized molecules in transfected L cells is impaired at some point along the pathway from the rough endoplasmic reticulum (RER) to the medial-, trans-Golgi apparatus.

【 授权许可】

Unknown