Lipid parameters in a hypofunctioning thyroid gland

International Journal of Biomedical and Advance Research

Madan Gopal¹  Dr. Sushith¹  Ashok Kumar¹  Mohammed Ali Imthiaz U.¹  Shashikala S.¹  Reshma S.¹  Prathima M. B.¹ 

关键词: overt hypothyroidism;    Lipids;    dyslipidemia;    atherosclerosis;   

DOI  :  10.7439/ijbar.v6i10.2597

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Background:Hypofunctioning of the thyroid gland is associated with lipid abnormalities. There is an inverse relation between the lipid parameters and the thyroid hormones. Management of such abnormalities becomes essential in hypothyroid patients to prevent any cardiovascular complications. In this study various lipid parameters were analysed in patients with overt hypothyroidism. Methods:Lipid parameters such as total cholesterol, HDL cholesterol, triglycerides, LDL cholesterol were analysed in a total of 52 subjects which included 27 patients with overt hypothyroidism and 25 healthy controls. A serum level of total TSH of >20 uIU/L was included as overt hypothyroids in the study. Results : The mean age of the overt hypothyroids was 39.56?13.01 years, among which 78.6% were females. There was a statistically significant increase in total cholesterol, LDL cholesterol and triglycerides among the cases with a significant decrease in HDL cholesterol. Conclusion : Hypofunctioning of the thyroid gland is associated with deranged lipid parameters. This study shows that dyslipidemia could be a complication of overt hypothyroidism and periodic assessment of lipid profile may be essential in these patients.

【 授权许可】

CC BY