An In-vitro study of Lipid peroxidation, Vitamin E and Vitamin C levels in saliva of oral precancerous patients in Distt Hapur of U.P.

International Journal of Biomedical and Advance Research

Akash Gupta¹  Dilutpal Sharma¹  Sowmya MK¹  Prasanna Chandra¹ 

关键词: Lipid peroxidation;    MDA;    Vitamin E;    Vitamin C;    Oral precancerous lesion;   

DOI  :  10.7439/ijbar.v4i4.330

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Objective:The objective of our study was to find out whether vitamin E and vitamins C levels in saliva can be used as a marker for cancer. ????? Material and Methods:This study was carried out in the dental OPD of Saraswathi Institute of Medical Sciences, Hapur, U.P. ?The saliva was collected from all the subjects. Results were compared with age, sex and matched with controls. Total 20 people were selected in which 10 normal subjects and 10 oral pre cancerous patients. Saliva was estimated for lipid peroxidation (malondialdehyde MDA), Vitamin E and C levels respectively. ?? Results:Our results indicated significant increase in lipid peroxidation (MDA) in oral precancerous stages but there was decrease in vitamin E and C levels. This suggests that there is an increase oxidative stress in oral precancerous lesion and may further increase in cancerous stages. ?? Conclusion:Free radical induced lipid peroxidation causes a loss of cell homeostasis by modifying the structure and functions of cell membrane. Their chief dangers come from damage they can do when they react with important cellular components such as DNA or the cell membrane. To prevent free radical damage body has a defense system of anti oxidants which are involved in the prevention of cellular damage ?the common pathway for cancer ageing and a variety of diseases.

【 授权许可】

CC BY