Challenges and outcomes of a randomized study of early nutrition support during autologous stem-cell transplantation

Current Oncology

N. Kiss¹  M. Prince¹  G. Dutu¹  J. Seymour¹ 

[1]Peter MacCallum Cancer Centre

关键词: Nutrition;    Autologous stem cell transplant;    Malnutrition;    Enteral nutrition;    Parenteral nutrition;   

DOI  :  

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

Patients undergoing myeloablative conditioning regimens and autologous stem-cell transplantation (asct) are at high risk of malnutrition. This randomized study aimed to determine if early nutrition support (commenced when oral intake is less than 80% of estimated requirements) compared with usual care (commenced when oral intake is less than 50% of estimated requirements) reduces weight loss in wellnourished patients undergoing high-nutritional-risk conditioning chemotherapy and asct.In the 50 well-nourished patients who were randomized, the outcomes evaluated included changes in weight and lean body mass (mid-upper arm circumference), length of stay, time to hemopoietic engraftment, and quality of life (Memorial Symptom Assessment Scale – Short Form). On secondary analysis, after exclusion of a single extreme outlier, both groups demonstrated significant weight loss over time (p = 0.0005). Weight loss was less in the early nutrition support group at time of discharge (mean: –0.4% ± 2.9% vs. –3.4% ± 2.6% in the usual care group, p = 0.001). This difference in weight was no longer observed at 6 months after discharge (mean: –1.0% ± 6.8% vs. 1.4% ± 6.1%, p = 0.29).In practice, an early start to nutrition support proved difficult because of patient resistance and physician preference, with 8 patients (33%) in the control group and 4 (15%) in the intervention group not commencing nutrition support when stipulated by the study protocol. No significant differences between the groups were found for other outcomes. In wellnourished patients receiving asct, early nutrition support maintained weight during admission, but did not affect other outcomes. Interpretation of results should take into consideration the difficulties encountered with intervention implementation.

【 授权许可】

Unknown