Antibacterial Activity of B-Cyclodextrin and 2-Hydroxypropyl-B-Cyclodextrin Trimethoprim Complexes | Science Publications

American Journal of Microbiology

Helen McDonald¹  Gary D. Grant¹  Wayne Monaghan¹  Perrea Dunn¹  Jennifer C. Wilson¹  Briohny Spencer¹  Madhumathi Seshadri¹  Scott Lingard¹  Joan Faoagali¹  Ian Peak¹  Hsien-Kuo Sun¹  Michelle King¹  Alison Haywood¹  Enoch Chan¹  Todd Houston¹ 

关键词: Antibacterial activity;    trimethoprim;    2-hydroxypropyl;    B-cyclodextrin;    inclusion complex;    antimicrobial activity;    caco-2 cells;    Differential Scanning Calorimetry (DSC);   

DOI  :  10.3844/ajmsp.2011.1.8

学科分类：微生物学和免疫学

来源: Science Publications

【 摘 要 】

Cyclodextrin complexation has previously been shown to improve the solubility and dissolution properties of trimethoprim; however, no report provides an account of the effect cyclodextrin complexation has on the antibacterial activity of this agent

【 授权许可】

Unknown