Química Nova | |
Development and validation of a UV spectrophotometric method to quantify carvedilol | |
Stulzer, Hellen Karine1  Borba, Paola Aline Amarante1  Pereira, Rafael Nicolay1  Universidade Estadual de Ponta Grossa, Ponta Grossa, Brasil1  Universidade Federal de Santa Catarina, Florianópolis, Brasil1  Vecchia, Debora Dalla1  Riekes, Manoela Klüppel1  | |
关键词: carvedilol; UV spectrophotometry; validation.; | |
DOI : 10.1590/S0100-40422013000400017 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
This paper reports the development and validation of a new analytical method using UV spectrophotometry to quantify carvedilol (CRV) in hydrophilic matrices and raw material. This method was shown to be linear, accurate, precise, robust and to have adequate limits of quantification and detection (LQ and LD, respectively), allowing its use in the dissolution test of hydrophilic matrices. The content of CRV determined through this method was compared with two previously validated methods based on the reference techniques of High Performance Liquid Chromatography (HPLC) and Potentiometric Titrations (PT). ANOVA confirmed the equivalence of these methods, showing no significant differences.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050595998ZK.pdf | 371KB | download |