Spectrophotometric Estamation of Meloxicam Using Charge Transfer Complex

2nd International Scientific Conference (Pure Sciences, Brilliant Creativity and Renewed Building)

Mahood, Abdulbari Mahdi^1 ; Najm, Nahawnd H.^2

Department of Pharmaceutical Chemisitry, Faculty of Pharmacy, Iraq^1

Department of Chemistry, Faculty of Education for Pure Sciences, University of Kerbala, Iraq^2

关键词: Accuracy and precision;    Charge transfer complex;    Correlation coefficient;    Detection limits;    Maximum absorbance;    Meloxicam;    Pharmaceutical preparations;    UV spectrophotometry;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/571/1/012081/pdf
DOI  :  10.1088/1757-899X/571/1/012081

来源: IOP

【 摘 要 】

In this study we developed cheap and precise analytic method to measure Meloxicam concentration in bulk and pharmaceutical formula. The method based on the reaction between ferric ion and Meloxicam to yield ferrous ion. Then the former ion Fe2+ reacted coupled with potassium ferric cyanide to forming colored compound has a maximum absorbance at 708 nm. The method was validated by calculating the precision and accuracy. The method follows Beer-Lamber law at a range of (0.1-11) μg/mL with correlation coefficient is 0.9978. Accuracy and precision of the proposed method were estimated and shown average of recoveries between (98.7-99.5 %) with precision represented by RSD% equal to 0.56. We also calculated the detection limit (LOD) and quantitative of limit (LOQ) were 0.0092 μg/mL 0.030 μg/mL respectively The modified suggested method was used to measure Meloxicam in pharmaceutical preparation without additives interference and shows a good agreement with the standard method. Therefore, it can be used for routine works for quality control for estimation of the Meloxicam in bulk and pharmaceutical preparation as tablets.