Quimica nova | |
Development and validation of a UV spectrophotometric method to quantify carvedilol | |
Vecchia, Debora Dalla1  Stulzer, Hellen Karine2  Borba, Paola Aline Amarante2  Pereira, Rafael Nicolay2  Riekes, Manoela Klüppel2  | |
[1] Universidade Estadual de Ponta Grossa, Ponta Grossa, Brasil;Universidade Federal de Santa Catarina, Florianópolis, Brasil | |
关键词: carvedilol; UV spectrophotometry; validation.; | |
DOI : 10.1590/S0100-40422013000400017 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
This paper reports the development and validation of a new analytical method using UV spectrophotometry to quantify carvedilol (CRV) in hydrophilic matrices and raw material. This method was shown to be linear, accurate, precise, robust and to have adequate limits of quantification and detection (LQ and LD, respectively), allowing its use in the dissolution test of hydrophilic matrices. The content of CRV determined through this method was compared with two previously validated methods based on the reference techniques of High Performance Liquid Chromatography (HPLC) and Potentiometric Titrations (PT). ANOVA confirmed the equivalence of these methods, showing no significant differences.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201902014262840ZK.pdf | 371KB | download |