Poly(ethylene-co-methyl acrylate)/poly(caprolactone) triol blends for drug delivery systems: characterization and drug release

Química Nova

Soldi, Valdir¹  Universidade do Sul de Santa Catarina, Tubarão, Brasil¹  Kanis, Luiz A.¹  Universidade Federal de Santa Catarina, Florianópolis, Brasil¹ 

关键词: blends;    poly(caprolactone) triol;    drug release.;   

DOI  :  10.1590/S0100-40422012000200012

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Poly(ethylene-co-methyl acrylate) (EMA) and poly (caprolactone) triol (PCL-T) blends, a biodegradable aliphatic polyester with low molecular weight and moderate water solubility containing diltiazem hydrochloride (DZ) were studied in terms of the thermal and morphological properties, and drug release mechanism. An increase in the PCL-T content in the EMA/PCL-T/DZ films decreased the degree of DZ crystallinity. Drug release from these films is temperature-dependent, and it is possible to modify the drug release rate by adjusting the EMA/PCL-T composition of the blends. The mechanism of drug release is governed by PCL-T melting and PCL-T leaching from EMA matrix.

【 授权许可】

Unknown