Poly(ethylene-co-methyl acrylate)/poly(caprolactone) triol blends for drug delivery systems: characterization and drug release

Quimica nova

Soldi, Valdir¹  Kanis, Luiz A.² 

[1] Universidade Federal de Santa Catarina, Florianópolis, Brasil;Universidade do Sul de Santa Catarina, Tubarão, Brasil

关键词: blends;    poly(caprolactone) triol;    drug release.;   

DOI  :  10.1590/S0100-40422012000200012

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Poly(ethylene-co-methylacrylate) (EMA) and poly (caprolactone) triol (PCL-T) blends, a biodegradablealiphatic polyester with low molecular weight and moderate water solubilitycontaining diltiazem hydrochloride (DZ) were studied in terms of the thermaland morphological properties, and drug release mechanism. An increase in thePCL-T content in the EMA/PCL-T/DZ films decreased the degree of DZ crystallinity.Drug release from these films is temperature-dependent, and it is possible tomodify the drug release rate by adjusting the EMA/PCL-T composition of the blends.The mechanism of drug release is governed by PCL-T melting and PCL-T leachingfrom EMA matrix.

【 授权许可】

CC BY