Thermal analysis applied to drugs and pharmaceutical formulations in pharmaceutical industry

Química Nova

Lima Gomes, Elionai Cassiana de¹  Universidade Federal do Espírito Santo, São Mateus, Brasil¹  Yoshida, Maria Irene¹  Oliveira, Marcelo Antonio de¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹ 

关键词: thermal analysis;    pharmaceutical industry;    characterization.;   

DOI  :  10.1590/S0100-40422011000700022

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Several matters of the pharmaceutical demonstrate the great importance of thermal analysis application, especially TG and DSC for the pharmaceutical industry future, namely: characterization of the drugs with the thermal events definition, in studies of drug purity, in the polymorphs identification, in compatibility studies of solid dosage pharmaceutical formulations, in drugs and pharmaceutical formulations thermal stability, and in determination of shelf life for isothermal degradation kinetics by extrapolation using the Arrhenius equation. Thus, the test results obtained from thermal analysis are directly related to the quality of a pharmaceutical product, whether the stability or bioavailability of the pharmaceutical product.

【 授权许可】

Unknown