Development and validation of UV spectrophotometric method for determination of levofloxacin in pharmaceutical dosage forms

Química Nova

Amaral, Marcos Serrou do¹  Singh, Anil Kumar¹  Universidade de São Paulo, São Paulo, Brasil¹  Santoro, Maria Inês Rocha Miritello¹  Universidade Federal de Mato Grosso do Sul, Campo Grande, Brasil¹  Kassab, Nájla Mohamad¹ 

关键词: fluoroquinolone;    UV spectrophotometry;    quality control.;   

DOI  :  10.1590/S0100-40422010000400037

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The objective of this research was to develop and validate an alternative analytical method for quantitative determination of levofloxacin in tablets and injection preparations. The calibration curves were linear over a concentration range from 3.0 to 8.0 μg mL-1. The relative standard deviation was below 1.0% for both formulations and average recovery was 101.42 ± 0.45% and 100.34 ± 0.85% for tablets and injection formulations, respectively. The limit of detection and limit of quantitation were 0.08 and 0.25 μg mL-1, respectively. It was concluded that the developed method is suitable for the quality control of levofloxacin in pharmaceuticals formulations.

【 授权许可】

Unknown