Spectrophotometric determination of sildenafil citrate in pharmaceutical formulations

Química Nova

Pezza, Leonardo¹  Universidade Estadual Paulista¹  Pezza, Helena Redigolo¹  Weinert, Patrícia Los¹ 

关键词: sildenafil citrate;    p-;    chloranil;    spectrophotometry.;   

DOI  :  10.1590/S0100-40422008000500033

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This paper describes a simple and rapid spectrophotometric method for quantitative determination of sildenafil citrate based on its reaction with p-chloranil accelerated by hydrogen peroxide, producing a stable purple compound (λmax= 535 nm). In the absence of peroxide this reaction is very slow. The experimental conditions were optimized by using response surface methodologies. Beer's law is obeyed in a concentration range of 8.52 x 10-5 – 1.70 x 10-3 mol L-1 (r = 0.999). The detection limit was 1.96 x 10-5 mol L-1. The method was successfully applied for the determination of sildenafil citrate in medicines with good accuracy and precision.

【 授权许可】

Unknown