INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE

Journal of The Chilean Chemical Society

LI, YAN¹  ZHAO, QING-HUA¹  DU, LI-MING¹  XIE, JIAN-HONG¹  FU, YUN-LONG¹  CHEN, CAI-PING¹  PANG, TAO-TAO¹ 

[1] Shanxi Normal University, Linfen, China

关键词: Tramadol hydrochloride;    Spectrofluorometry;    Supramolecular interaction;    p-;    sulfonated calyx[;    n];    arene;   

DOI  :  10.4067/S0717-97072015000400007

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

In this paper, the interaction behavior of p-sulfonated calix[n]arene (SCnA) with tramadol hydrochloride was investigated by fluorescence spectra, 1H NMR spectra, and theoretical calculations in aqueous solution. At the optimized conditions, the fluorescence intensity of tramadol hydrochloride showed positive correlation to the concentration of SCnA, which led to a validated, simple, and sensitive fluorescence quenching method for the determination of tramadol hydrochloride was established for the first time. Moreover, the interaction based on SCnA superstructure provided has promising potential for therapeutic monitoring and pharmacokinetics and clinical application

【 授权许可】

Unknown