Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity

Química Nova

França, Suzelei de Castro¹  Universidade de Ribeirão Preto, Ribeirão Preto, Brasil¹  Pereira, Sarazete Izidia Vaz¹  Sampaio, Suely Vilela¹  Pereira, Paulo Sérgio¹  Universidade de São Paulo, Ribeirão Preto, Brasil¹  Breves, Camila Moniz de Souza¹  Dias, Diones Aparecida¹  Nomizo, Auro¹  Oliveira, Paulo Vinicius Anderson de¹ 

关键词: Tabernaemontana catharinensis;    indole alkaloids;    cytotoxicity.;   

DOI  :  10.1590/S0100-40422008000100004

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae). Among the 27 substances detected 12 were identified as terpenoid-indole alkaloids, 2 steroids and 13 pentacyclic triterpenes. Structures were outlined based on HMQC, COSY, DEPT, 13C, and 1H NMR data and MS. Spectral data of indole alkaloids were reviewed. An in vitro screening of the extracts and isolated compounds was carried out. Compounds ibogamine (5), 3-oxo-coronaridine (9) and 12-methoxy-4-methylvoachalotine (MMV) demonstrated effective cytotoxicity towards SKBR-3 breast adenocarcinoma and C-8161 human melanoma tumor cell lines.

【 授权许可】

Unknown