Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity

Quimica nova

França, Suzelei de Castro¹  Pereira, Sarazete Izidia Vaz¹  Pereira, Paulo Sérgio¹  Breves, Camila Moniz de Souza¹  Oliveira, Paulo Vinicius Anderson de¹  Sampaio, Suely Vilela²  Nomizo, Auro²  Dias, Diones Aparecida² 

[1] Universidade de Ribeirão Preto, Ribeirão Preto, Brasil;Universidade de São Paulo, Ribeirão Preto, Brasil

关键词: Tabernaemontana catharinensis;    indole alkaloids;    cytotoxicity.;   

DOI  :  10.1590/S0100-40422008000100004

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work describes the isolation and structuraldetermination of pharmacological compounds present in the bark of roots of Tabernaemontanacatharinensis (Apocynaceae). Among the 27 substances detected 12 were identifiedas terpenoid-indole alkaloids, 2 steroids and 13 pentacyclic triterpenes. Structureswere outlined based on HMQC, COSY, DEPT, 13C, and 1H NMRdata and MS. Spectral data of indole alkaloids were reviewed. An in vitroscreening of the extracts and isolated compounds was carried out. Compoundsibogamine (5), 3-oxo-coronaridine (9) and 12-methoxy-4-methylvoachalotine(MMV) demonstrated effective cytotoxicity towards SKBR-3 breast adenocarcinomaand C-8161 human melanoma tumor cell lines.

【 授权许可】

CC BY