Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity

Química Nova

Paulo Sérgio Pereira²  Suzelei De Castro França²  Paulo Vinicius Anderson De Oliveira²  Camila Moniz De Souza Breves²  Sarazete Izidia Vaz Pereira²  Suely Vilela Sampaio¹  Auro Nomizo¹  Diones Aparecida Dias¹ 

[1] ,Universidade de Ribeirão Preto Unidade de Biotecnologia Ribeirão Preto SP ,Brasil

关键词: Tabernaemontana catharinensis;    indole alkaloids;    cytotoxicity;   

DOI  :  10.1590/S0100-40422008000100004

来源: SciELO

【 摘 要 】

This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae). Among the 27 substances detected 12 were identified as terpenoid-indole alkaloids, 2 steroids and 13 pentacyclic triterpenes. Structures were outlined based on HMQC, COSY, DEPT, 13C, and ¹H NMR data and MS. Spectral data of indole alkaloids were reviewed. An in vitro screening of the extracts and isolated compounds was carried out. Compounds ibogamine (5), 3-oxo-coronaridine (9) and 12-methoxy-4-methylvoachalotine (MMV) demonstrated effective cytotoxicity towards SKBR-3 breast adenocarcinoma and C-8161 human melanoma tumor cell lines.

【 授权许可】

CC BY-NC   
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