Antioxidants in the skin: applications and evaluation of their efficacy

Química Nova

Colepicolo, Pio¹  Universidade de São Paulo, São Paulo, Brasil¹  Medeiros, Marisa H. G.¹  Guaratini, Thais¹ 

关键词: skin;    antioxidants;    efficacy.;   

DOI  :  10.1590/S0100-40422007000100033

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The skin is a very complex organ, continuously exposed to physical, chemical and microbiological agents. Enzymes as well as low-molecular weight antioxidants are present in the cutaneous tissue to counterbalance the deleterious effect caused by an oxidative stress and thus maintain homeostasis. Antioxidants such as vitamins C and E, carotenoids, and extracts with these properties have been extensively used for treatment of pathologies and skin aging prevention. We review here different mechanisms that can interfere in the redox equilibrium of the skin, as well as the chemical reactions involved in these processes. Moreover, we discuss the importance of endogenous or exogenous antioxidants that can be acquired from the diet or from oral or topical administration, and methodologies that have been developed to evaluate their efficacy.

【 授权许可】

Unknown