On the application of knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study

Química Nova

Barbosa Filho, José Maria¹  Universidade Católica de Pernambuco, Brasil¹  Pitta, Ivan da Rocha¹  Universidade Federal de Ouro Preto, Ouro Preto, Brasil¹  Guarda, Vera Lucia de Miranda¹  Universidade Federal da Paraíba, Brasil¹  Leite, Lúcia Fernanda Cavalcanti da Costa¹  Souza, Ana Maria Alves de¹  Universidade Federal de Pernambuco, Recife, Brasil¹  Galdino, Suely Lins¹  Universidade Federal de Pernambuco, Brasil¹  Lima, Maria do Carmo Alves de¹ 

关键词: benzothiazines;    benzylidene benzothiazines;    AM1 conformational and configurational analysis.;   

DOI  :  10.1590/S0100-40422006000500035

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The synthesis and physico-chemical properties of new 6-acetylamino or 6-benzoyl-amino 2-benzylidene-4-methyl-4H-benzo[1,4]thiazin-3-ones and 6-benzoylamino or 6-nitro 2-benzylidene-4H-benzo[1,4]thiazin-3-ones are described. These benzylidene benzothiazine compounds were prepared by the Knoevenagel condensation with benzaldehydes. The configurations and conformations of benzylidene benzothiazine derivatives were optimised using the semi-empirical method AM1.

【 授权许可】

Unknown