On the application of knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study

Quimica nova

Leite, Lúcia Fernanda Cavalcanti da Costa¹  Barbosa Filho, José Maria²  Guarda, Vera Lucia de Miranda³  Souza, Ana Maria Alves de⁴  Pitta, Ivan da Rocha⁵  Galdino, Suely Lins⁵  Lima, Maria do Carmo Alves de⁵ 

[1] Universidade Católica de Pernambuco, Brasil;Universidade Federal da Paraíba, Brasil;Universidade Federal de Ouro Preto, Ouro Preto, Brasil;Universidade Federal de Pernambuco, Brasil;Universidade Federal de Pernambuco, Recife, Brasil

关键词: benzothiazines;    benzylidene benzothiazines;    AM1 conformational and configurationalanalysis.;   

DOI  :  10.1590/S0100-40422006000500035

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The synthesis andphysico-chemical properties of new 6-acetylamino or 6-benzoyl-amino 2-benzylidene-4-methyl-4H-benzo[1,4]thiazin-3-onesand 6-benzoylamino or 6-nitro 2-benzylidene-4H-benzo[1,4]thiazin-3-onesare described. These benzylidene benzothiazine compounds were prepared by theKnoevenagel condensation with benzaldehydes. The configurations and conformationsof benzylidene benzothiazine derivatives were optimised using the semi-empiricalmethod AM1.

【 授权许可】

CC BY