On the application of knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study

Química Nova

Ana Maria Alves De Souza²  Vera Lucia De Miranda Guarda¹  Lúcia Fernanda Cavalcanti Da Costa Leite¹  José Maria Barbosa Filho¹  Maria Do Carmo Alves De Lima¹  Suely Lins Galdino¹  Ivan Da Rocha Pitta¹ 

[1] ,Universidade Federal de Pernambuco,Brasil

关键词: benzothiazines;    benzylidene benzothiazines;    AM1 conformational and configurational analysis;   

DOI  :  10.1590/S0100-40422006000500035

来源: SciELO

【 摘 要 】

The synthesis and physico-chemical properties of new 6-acetylamino or 6-benzoyl-amino 2-benzylidene-4-methyl-4H-benzo[1,4]thiazin-3-ones and 6-benzoylamino or 6-nitro 2-benzylidene-4H-benzo[1,4]thiazin-3-ones are described. These benzylidene benzothiazine compounds were prepared by the Knoevenagel condensation with benzaldehydes. The configurations and conformations of benzylidene benzothiazine derivatives were optimised using the semi-empirical method AM1.

【 授权许可】

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