Recent achievements to combat bacterial resistance

Química Nova

Silveira, Gustavo Pozza¹  Terenzi, Hernán¹  Nome, Faruk¹  Sá, Marcus Mandolesi¹  Universidade Federal de Santa Catarina, Florianópolis, Brasil¹  Gesser, José Carlos¹ 

关键词: Gram-positive bacteria;    bacterial resistance;    vancomycin.;   

DOI  :  10.1590/S0100-40422006000400037

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This article provides an overview on the recent achievements to combat Gram-positive bacteria and the mechanisms related to antimicrobial activity and bacterial resistance. Selected synthetic methodologies to access structurally diverse bioactive compounds are presented in order to emphasize the most important substances currently developed to overcome multiresistant strains. The main properties of vancomycin and related glycopeptide antibiotics are also discussed as a background to understanding the design of new chemotherapeutic agents.

【 授权许可】

Unknown