Recent achievements to combat bacterial resistance

Quimica nova

Silveira, Gustavo Pozza¹  Terenzi, Hernán¹  Nome, Faruk¹  Sá, Marcus Mandolesi¹  Gesser, José Carlos¹ 

[1] Universidade Federal de Santa Catarina, Florianópolis, Brasil

关键词: Gram-positive bacteria;    bacterial resistance;    vancomycin.;   

DOI  :  10.1590/S0100-40422006000400037

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This article providesan overview on the recent achievements to combat Gram-positive bacteria andthe mechanisms related to antimicrobial activity and bacterial resistance. Selectedsynthetic methodologies to access structurally diverse bioactive compounds arepresented in order to emphasize the most important substances currently developedto overcome multiresistant strains. The main properties of vancomycin and relatedglycopeptide antibiotics are also discussed as a background to understandingthe design of new chemotherapeutic agents.

【 授权许可】

CC BY