Estratégias utilizadas no combate a resistência bacteriana

Química Nova

Gustavo Pozza Silveira¹  Faruk Nome¹  José Carlos Gesser¹  Marcus Mandolesi Sá¹  Hernán Terenzi² 

[1] ,Universidade Federal de Santa Catarina Departamento de Química Florianópolis SC ,Brasil

关键词: Gram-positive bacteria;    bacterial resistance;    vancomycin;   

DOI  :  10.1590/S0100-40422006000400037

来源: SciELO

【 摘 要 】

This article provides an overview on the recent achievements to combat Gram-positive bacteria and the mechanisms related to antimicrobial activity and bacterial resistance. Selected synthetic methodologies to access structurally diverse bioactive compounds are presented in order to emphasize the most important substances currently developed to overcome multiresistant strains. The main properties of vancomycin and related glycopeptide antibiotics are also discussed as a background to understanding the design of new chemotherapeutic agents.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License