Screening for acetylcholinesterase inhibitors from plants to treat Alzheimer's disease

Química Nova

Macedo, Fábio Vanderlan Viana¹  Meent, Michiel van de¹  Rhee, In Kyung¹  Verpoorte, Rob¹  Leiden University, The Netherlands¹  Trevisan, Maria Teresa Salles¹  Universidade Federal do Ceará, Fortaleza, Brasil¹ 

关键词: Alzheimer disease;    plants;    cholinesterase inhibitors.;   

DOI  :  10.1590/S0100-40422003000300002

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognite impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinergic activities. These symptons of AD have been successfully treated with acetylcholinesterase (AchE) inhibitors (eg. galanthamine). There still is great interest in finding better AchE inhibitors. We use Ellmann's microplate assay and silica gel thin-layer chromatography (TLC) to screen natural products from plants as new sources of AchE inhibitors.

【 授权许可】

Unknown