Screening for acetylcholinesterase inhibitors from plants to treat Alzheimer's disease

Quimica nova

Meent, Michiel van de¹  Rhee, In Kyung¹  Verpoorte, Rob¹  Macedo, Fábio Vanderlan Viana²  Trevisan, Maria Teresa Salles² 

[1] Leiden University, The Netherlands;Universidade Federal do Ceará, Fortaleza, Brasil

关键词: Alzheimer disease;    plants;    cholinesterase inhibitors.;   

DOI  :  10.1590/S0100-40422003000300002

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Alzheimer'sdisease (AD) is a neurodegenerative disease characterized by cognite impairmentand personality changes. The development of drugs for the treatment of the cognitivedeficits of AD has focused on agents which counteract loss in cholinergic activities.These symptons of AD have been successfully treated with acetylcholinesterase(AchE) inhibitors (eg. galanthamine). There still is great interest in findingbetter AchE inhibitors. We use Ellmann's microplate assay and silica gel thin-layerchromatography (TLC) to screen natural products from plants as new sources ofAchE inhibitors.

【 授权许可】

CC BY