Seleção de plantas com atividade anticolinasterase para tratamento da doença de Alzheimer

Química Nova

Maria Teresa Salles Trevisan²  Fábio Vanderlan Viana Macedo²  Michiel Van De Meent¹  In Kyung Rhee¹  Rob Verpoorte¹ 

[1] ,Universidade Federal do Ceará Centro de Ciências Departamento de Química Orgânica e InorgânicaFortaleza CE ,Brasil

关键词: Alzheimer disease;    plants;    cholinesterase inhibitors;   

DOI  :  10.1590/S0100-40422003000300002

来源: SciELO

【 摘 要 】

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognite impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinergic activities. These symptons of AD have been successfully treated with acetylcholinesterase (AchE) inhibitors (eg. galanthamine). There still is great interest in finding better AchE inhibitors. We use Ellmann's microplate assay and silica gel thin-layer chromatography (TLC) to screen natural products from plants as new sources of AchE inhibitors.

【 授权许可】

CC BY-NC   
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