Solid-Phase Peptide Synthesis of Dipeptide (Histidine-β-Alanine) as a Chelating Agent by Using Trityl Chloride Resin, for Removal of Al3+, Cu2+, Hg2+ and Pb2+: Experimental and Theoretical Study

Journal of the Brazilian Chemical Society

Safavi, Ebrahim¹  Rahimi, Rahmatollah¹  Tehrani, Mohammd H. H.¹  World Society of the Anti-Aging Medicine, Tehran, Iran¹  Iran University of Science and Technology, Tehran, Iran¹  Rabbani, Mahboubeh¹  Shahid Beheshti University of Medical Sciences, Tehran, Iran¹  Khosravi, Maryam¹ 

关键词:  dipeptide;    solid-phase peptide synthesis;    trityl chloride resin;    chelating property;    PASS program;   

DOI  :  10.5935/0103-5053.20160064

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Solid-phase peptide synthesis of dipeptide (histidine-β-alanine) as a chelating agent examined by common N-9-fluorenylmethyloxycarbonyl-N-trityl-L-histidine and tert-butyloxycarbonyl-β-alanine-OH amino acid derivatives. Trityl chloride resin was used as a carrier resin. The molecular structure of the dipeptide was definite by using different methods such as ultraviolet visible (UV-Vis), Fourier transform infrared (FTIR), proton (1H) nuclear magnetic ressonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) and the chelating property of synthesized dipeptide was investigated for removing of metal ions Al3+, Cu2+, Hg2+ and Pb2+in vitro. In addition, the pharmacological and biological activities of dipeptide were examined by prediction of activity spectra for substances (PASS) program.

【 授权许可】

Unknown