TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B

Molecules

Yahya E. Jad¹  Sherine N. Khattab²  Beatriz G. de la Torre¹  Thavendran Govender¹  Hendrik G. Kruger¹  Ayman El-Faham²  Fernando Albericio¹ 

[1] Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa; E-Mails:;Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt; E-Mail:

关键词: coupling reagents;    solid-phase peptide synthesis;    peptide synthesis;    Oxyma-B;    amino acids;   

DOI  :  10.3390/molecules191118953

来源: mdpi

【 摘 要 】

Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.