Chemical characterization of essential oils from Drimys angustifolia miers (Winteraceae) and antibacterial activity of their major compounds

Journal of the Brazilian Chemical Society

Dognini, Jocinei¹  Santos, Thalita G.¹  Begnini, Iêda M.¹  Universidade Regional de Blumenau (FURB), Blumenau, Brazil¹  Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil¹  Gasper, André L. de¹  Verdi, Marcio¹  Rebelo, Ricardo A.¹  Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil¹  Dalmarco, Eduardo M.¹ 

关键词: Drimys angustifolia;    essential oils;    drimenol;    bicyclogermacrene;    antibacterial activity;   

DOI  :  10.1590/S0103-50532013000100020

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Essential oils have been extensively studied in recent years as a natural source of new antimicrobial agents. In this work, essential oils of leaf and branch from Drimys angustifolia growing in Southern Brazil were obtained by hydrodistillation and analyzed by gas chromatographies with flame ionization detector (GC-FID) and with mass spectrometer (GC-MS). Drimenol and bicyclogermacrene were isolated by column chromatography from branch and leaf essential oils, respectively. Oils, isolated compounds and combinations of them were assayed against Gram-(+) and Gram-(–) bacteria. The oils showed to be more active against Bacillus cereus, with minimum inhibitory concentration (MIC) 125 and 250 µg mL-1 for branch and leaf oils, respectively, strongly inhibiting bacterial growth. Bicyclogermacrene was more active then drimenol, providing a MIC value of 167 µg mL-1 against B. cereus. Synergism was not observed in any of the combinations tested.

【 授权许可】

Unknown