Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensis

Revista Brasileira de Farmacognosia

Madson Ralide Fonseca Gomes²  Roselena Silvestri Schuh²  Ana Laura Bemvenuti Jacques²  Gilcéia G. Dorneles²  Jarbas Montanha¹  Paulo Michel Roehe¹  Sérgio Bordignon¹  Eliane Dallegrave¹  Mirna B. Leal¹  Renata Pereira Limberger² 

[1] ,Faculdade de Farmácia Laboratório de Toxicologia ,Brazil

关键词: acute toxicity;    antioxidant;    antiviral;    Drimys angustifolia;    Drimys brasiliensis;    essential oils;   

DOI  :  10.1590/S0102-695X2012005000142

来源: SciELO

【 摘 要 】

The genus Drimys presents the widest geographical distribution of the Winteraceae family, which comprises seven genera and about 120 species. In Brazil, the genus is found from Bahia to Rio Grande do Sul and occur in two species, Drimys angustifolia Miers, and D. brasiliensis Miers, Winteraceae, popularly known as "casca-de-anta", characterized by the presence of flavonoids and essential oils. It is used in folk medicine as an antiscorbutic, stimulant, antispasmodic, anti-diarrheal, antipyretic, antibacterial, and against asthma and bronchitis, besides having insecticidal properties. In addition to the known biological activities, it is very important to explore new applications in the treatment of physiological disorders or diseases caused by parasites. Based on this information, in this study we propose to evaluate volatile oils of the species D. brasiliensis and D. angustifolia, as an antioxidant, using the model of the DPPH radical as an antiviral against human herpes virus type 1 (HSV-1) and acute toxicity in vivo. The two species were not able to reduce the DPPH radical and showed interesting antiviral activity, significantly reducing the virus titers in vitro assays. Regarding the in vivo toxicity in female Wistar rats, treatment with the two species showed interesting signs in animals such as salivation, ptosis, tremor, decreased motor activity. In addition the oils of D. brasiliensis to other signs, some animals showed increased urination and diarrhea.

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