Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

Revista Brasileira de Farmacognosia

Santos, Claudio C. C.dos¹  Giongo, Viveca¹  Campos, Sylvia M. N.¹  Pedruzzi, Monique de M. B.¹  Ferreira, Wilton J.¹  Cavalcanti, Diana N.¹  Ocampo, Patrícia¹  Teixeira, Gerlinde A. P. B.¹  Garrido, Valéria¹  Instituto Oswaldo Cruz, Manguinhos, Brazil¹  Paixão, Izabel C. P.¹  Teixeira, Valéria L.¹  Universidade Federal Fluminense, Niterói, Brazil¹  Olaya, Patricia¹ 

关键词: Dictyota pfaffii;    dolabelladienotriol;    acute toxicity;    BALB/c mice;    diterpene;    antiviral;   

DOI  :  10.1590/S0102-695X2011005000053

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals´ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.

【 授权许可】

Unknown