Chemical characterization of essential oils from Drimys angustifolia miers (Winteraceae) and antibacterial activity of their major compounds

Journal of the Brazilian Chemical Society

Thalita G. Santos²  Jocinei Dognini²  Iêda M. Begnini²  Ricardo A. Rebelo²  Marcio Verdi¹  André L. De Gasper¹  Eduardo M. Dalmarco¹ 

[1] ,Universidade Regional de Blumenau (FURB) Departamento de Química Blumenau SC ,Brazil

关键词: Drimys angustifolia;    essential oils;    drimenol;    bicyclogermacrene;    antibacterial activity;   

DOI  :  10.1590/S0103-50532013000100020

来源: SciELO

【 摘 要 】

Essential oils have been extensively studied in recent years as a natural source of new antimicrobial agents. In this work, essential oils of leaf and branch from Drimys angustifolia growing in Southern Brazil were obtained by hydrodistillation and analyzed by gas chromatographies with flame ionization detector (GC-FID) and with mass spectrometer (GC-MS). Drimenol and bicyclogermacrene were isolated by column chromatography from branch and leaf essential oils, respectively. Oils, isolated compounds and combinations of them were assayed against Gram-(+) and Gram-(-) bacteria. The oils showed to be more active against Bacillus cereus, with minimum inhibitory concentration (MIC) 125 and 250 µg mL-1 for branch and leaf oils, respectively, strongly inhibiting bacterial growth. Bicyclogermacrene was more active then drimenol, providing a MIC value of 167 µg mL-1 against B. cereus. Synergism was not observed in any of the combinations tested.

【 授权许可】

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