Multicomponent Biginelli's synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by SnCl2.2H2O

Journal of the Brazilian Chemical Society

Silva, Victor S. S. da¹  Godoi, Marla N.¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil¹  Canto, Karen F. S.¹  Russowsky, Dennis¹  D'Oca, Marcelo G. Montes¹  Fundação Universidade do Rio Grande, Rio Grande, Brazil¹  Lopes, Fabrício A.¹ 

关键词: Biginelli reaction;    multicomponent reaction;    dihydropyrimidinones;    tin(II) chloride hydrate;    Lewis acid;   

DOI  :  10.1590/S0103-50532004000200002

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described. The reaction was carried out in acetonitrile or ethanol as solvents in neutral media and represents an improvement of the classical Biginelli protocol and an advantage in comparison with FeCl3.6H2O, NiCl2.6H2O and CoCl2.6H2O which were used with HCl as co-catalyst. The synthesis of 3,4-dihydropyrimidinones was achieved in good to excelent yields.

【 授权许可】

Unknown