Anti-N-methyl-D Encephalitis

Innovations in Clinical Neuroscience

Adil Tumbi¹  Amin Gilani¹  Jonathan R. Scarff¹  Steven Lippmann¹  Gagandeep Kaur¹ 

[1] All from University of Louisville School of Medicine, Psychiatry Department, Louisville, Kentucky

关键词: Anti-N-methyl-D-aspartate receptor encephalitis;    limbic encephalitis;    NMDA receptors;    NMDA antibodies;    paraneoplastic syndrome;    autoimmune disorder;   

DOI  :  

学科分类：精神健康和精神病学

来源: Matrix Medical Communications, LLC

【 摘 要 】

Anti-N-methyl-D-aspartate receptor encephalitis is a rare and serious autoimmune disorder, usually part of a paraneoplastic syndrome. Patients present with a change in mental status, bizarre behavior, and seizures. There are many neoplastic and infectious etiologies, with 90 percent of documented cases in young women, frequently with an ovarian teratoma. Damage to limbic brain receptors is most often induced by teratoma cell-produced anti-N-methyl-D-aspartate antibodies. Treatment targets the specific oncologic or infectious cause and/or employs steroids, plasmapheresis, or other anti-inflammatory therapies. Neurological sequelae persist 75 percent of the time, relapse occurs in 20 percent of cases, and the mortality rate is 25 percent.

【 授权许可】

Unknown