Network-wide abnormalities explain memory variability in hippocampal amnesia

eLife

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[1] Memory Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;Memory Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;Institute of Cognitive Neuroscience, University College London, London, United Kingdom;Memory Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;Valdecilla Biomedical Research Institute, University Hospital Marqués de Valdecilla, Santander, Spain;Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;

关键词: hippocampus;    memory;    amnesia;    MRI;    limbic encephalitis;    cingulate;    Human;   

DOI  :  10.7554/eLife.46156

来源: publisher

【 摘 要 】

10.7554/eLife.46156.001Patients with hippocampal amnesia play a central role in memory neuroscience but the neural underpinnings of amnesia are hotly debated. We hypothesized that focal hippocampal damage is associated with changes across the extended hippocampal system and that these, rather than hippocampal atrophy per se, would explain variability in memory between patients. We assessed this hypothesis in a uniquely large cohort of patients (n = 38) after autoimmune limbic encephalitis, a syndrome associated with focal structural hippocampal pathology. These patients showed impaired recall, recognition and maintenance of new information, and remote autobiographical amnesia. Besides hippocampal atrophy, we observed correlatively reduced thalamic and entorhinal cortical volume, resting-state inter-hippocampal connectivity and activity in posteromedial cortex. Associations of hippocampal volume with recall, recognition, and remote memory were fully mediated by wider network abnormalities, and were only direct in forgetting. Network abnormalities may explain the variability across studies of amnesia and speak to debates in memory neuroscience.

【 授权许可】

CC BY