The Case for Hypofractionation of Localized Prostate Cancer

Reviews in Urology

Kent E Wallner²  Winnifred M Wong¹ 

[1] Department of Radiation Oncology, University of Washington,, Seattle, WA;Department of Radiation Oncology, Puget Sound Veterans Affairs Hospital,, Seattle, WA

关键词: Localized prostate cancer;    Hypofractionation;    Short-course radiotherapy;    Dose escalation;    Biologic equivalence;   

DOI  :  

学科分类：基础医学

来源: MedReviews, LLC

【 摘 要 】

An optimal treatment regimen for localized prostate cancer (PCa) is yet to be determined. Increasing evidence reveals a lower α/β ratio for PCa with hypofractionated radiation therapy (HFRT) regimens introduced to exploit this change in therapeutic ratio. HFRT also results in shortened overall treatment times of 4 to 5 weeks, thus reducing staffing and machine burden, and, more importantly, patient stress. This review evaluates pretreatment characteristics, outcomes, and toxicity for 15 HFRT studies on localized PCa. HFRT results in comparable or better biochemical relapse-free survival and toxicity and is a viable option for localized PCa.

【 授权许可】

Unknown