Combining Dosimetry & Toxicity: Analysis of two UK Phase III Clinical trials

17th International Conference on the Use of Computers in Radiation Therapy

物理学;计算机科学

Gulliford, Sarah L.^1

Joint Department of Physics, Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom^1

关键词: Analysis of data;    Clinical trial;    Data monitoring;    Dose distributions;    Dose escalation;    Prostate radiotherapy;    Radiotherapy treatment;    Rectal toxicity;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/489/1/012091/pdf
DOI  :  10.1088/1742-6596/489/1/012091

学科分类：计算机科学（综合）

来源: IOP

【 摘 要 】

There are many advantages to performing a clinical trial when implementing a novel radiotherapy technique. The clinical trials framework enables the safety and efficacy of the experimental arm to be tested and ensures practical support, rigorous quality control and data monitoring for participating centres. In addition to the clinical and follow-up data collected from patients within the trial, it is also possible to collect 3-D dosimetric information from the corresponding radiotherapy treatment plans. Analysing the combination of dosimetric, clinical and follow-up data enhances the understanding of the relationship between the dose delivered to both the target and normal tissue structures and reported outcomes & toxicity. Aspects of the collection, collation and analysis of data from two UK multicentre Phase III radiotherapy trials are presented here. MRC-RT01 dose-escalation prostate radiotherapy trial ISRCTN47772397 was one of the first UK multi-centre radiotherapy trials to collect 3-D dosimetric data. A number of different analysis methodologies were implemented to investigate the relationship between the dose distribution to the rectum and specific rectal toxicities. More recently data was collected from the PARSPORT trial (Parotid Sparing IMRT vs conventional head and neck radiotherapy) ISRCTN48243537. In addition to the planned analysis, dosimetric analysis was employed to investigate an unexpected finding that acute fatigue was more prevalent in the IMRT arm of the trial. It can be challenging to collect 3-D dosimetric information from multicentre radiotherapy trials. However, analysing the relationship between dosimetric and toxicity data provides invaluable information which can influence the next generation of radiotherapy techniques.