Bladder Cancer After Radiotherapy for Prostate Cancer

Reviews in Urology

Maurizio Buscarini¹  Federico Sergi¹  Francesca Suriano¹  Emanuela Altobelli¹ 

[1] Università Campus Bio-Medico di Roma,, Rome, Italy

关键词: Bladder cancer;    Prostate cancer;    Radiotherapy;    External beam radiotherapy;   

DOI  :  

学科分类：基础医学

来源: MedReviews, LLC

【 摘 要 】

External beam radiotherapy (EBRT) is frequently used in the management of prostate cancer (PCa) as definitive, postoperative, or salvage local treatment. Although EBRT plays a central role in the management of PCa, complications remain a troubling by-product. Several studies have demonstrated an association between radiotherapy and elevated risk of acute and late toxicities. A secondary malignancy induced by initial therapy represents one of the most serious complications related to definitive cancer treatment. The radiation-related secondary primary malignancy risk increases with increasing survival time. Transitional cell carcinoma of the bladder is the most frequent secondary primary malignancy occurring after radiotherapy and is described as more aggressive; it may be diagnosed later because some radiation oncologists believe that the hematuria that occurs after prostate EBRT is normal. Some patients treated for localized PCa will subsequently develop invasive bladder cancer requiring surgical intervention. Patients with PCa treated with EBRT should be monitored closely for the presence of bladder cancer.

【 授权许可】

Unknown