Reviews in Obstetrics and Gynecology | |
The KRAS-Variant Genetic Test As a Marker of Increased Risk of Ovarian Cancer | |
Florence K Keane1  Elena S Ratner1  | |
[1] Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT | |
关键词: Ovarian cancer; MicroRNA; KRAS-variant; Hereditary non-polyposis colorectal cancer; Oncomirs; | |
DOI : | |
学科分类:医学(综合) | |
来源: MedReviews, LLC | |
【 摘 要 】
Ovarian cancer (OC) is the fifth leading cause of cancer death in women. High mortality rates are due to vague symptoms of early disease, leading to diagnosis at a late stage. Approximately 10% of OCs are considered hereditary. The KRAS-variant is an inherited, germline variant that has been demonstrated to serve as a genetic marker of increased risk of OC. The KRAS-variant is easily tested in a blood or saliva sample, and has been shown to be at a high prevalence in OC patients. This test could serve as an answer to patients with a family history of ovarian and breast cancer without a previously identifiable genetic mutation.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912040559787ZK.pdf | 194KB | download |