The KRAS-Variant Genetic Test As a Marker of Increased Risk of Ovarian Cancer

Reviews in Obstetrics and Gynecology

Florence K Keane¹  Elena S Ratner¹ 

[1] Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT

关键词: Ovarian cancer;    MicroRNA;    KRAS-variant;    Hereditary non-polyposis colorectal cancer;    Oncomirs;   

DOI  :  

学科分类：医学（综合）

来源: MedReviews, LLC

【 摘 要 】

Ovarian cancer (OC) is the fifth leading cause of cancer death in women. High mortality rates are due to vague symptoms of early disease, leading to diagnosis at a late stage. Approximately 10% of OCs are considered hereditary. The KRAS-variant is an inherited, germline variant that has been demonstrated to serve as a genetic marker of increased risk of OC. The KRAS-variant is easily tested in a blood or saliva sample, and has been shown to be at a high prevalence in OC patients. This test could serve as an answer to patients with a family history of ovarian and breast cancer without a previously identifiable genetic mutation.

【 授权许可】

Unknown