An In Vitro Comparison of Antimicrobial Effects of Curcumin-Based Photodynamic Therapy and Chlorhexidine, on Aggregatibacter actinomycetemcomitans

Journal of Lasers in Medical Sciences

Abbas Bahador⁵  Shamsoulmolouk Najafi⁴  Mojgan Paknejad¹  Golfam Poursepanj²  Mina Khayamzadeh³  Mohammad Javad Kharazi Fard² 

[1] Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran$$;International Campus, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran$$;Department of Oral Medicine, International Campus, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran$$;Department of Oral Medicine, International Campus, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranDepartment of Dental Research Center and Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran$$;Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran$$

关键词: Aggregatibacter actinomycetemcomitans;   

DOI  :  10.22037/2010.v7i1.8058

学科分类：基础医学

来源: Shahid Beheshti University of Medical Sciences

【 摘 要 】

Introduction: Considering the importance of prevention in periodontal diseases and the important role of Aggregatibacter actinomycetemcomitans in induction and progression of these diseases, the aim of the present in vitro study was to compare the antimicrobial effects of chlorhexidine digluconate (CHX), curcumin and light-emitting diode (LED) laser, on this bacterium. Methods: Antimicrobial activity of curcumin (5 mg/ml), CHX (2%), LED (120 J/cm2) and LED + curcumin (120 J/cm2 + 2.5 mg/ml) against A. actinomycetemcomitans were tested in vitro, using micro-broth dilution test. One-way analysis of variance (ANOVA) and Tukey’s HSD tests served for statistical analysis. Results: Regarding the minimum inhibitory concentration (MIC), CHX had a significantly lower MIC than curcumin ( P < 0.05). Sorted out by bacterial growth from lowest to highest, were CHX, LED + curcumin, curcumin, and LED groups. All the differences were found to be statistically significant ( P < 0.05) except for the LED group. Conclusion: We conclude that curcumin is an effective substance in preventing the growth of A. actinomycetemcomitans , whose impact is reinforced when used simultaneously with photodynamic therapy (PDT).

【 授权许可】

Unknown