Synthesis, anti-microbial activity and molecular docking studies on triazolylcoumarin derivatives

Journal of Chemical Sciences

Devadasan Velmurugan¹  Mahalingam Ravivarma⁴  Vaithiyanathan Silambarasan¹  Perumal Rajakumar1⁴  Nanjian Raaman²  Chinnadurai Satheeshkumar1⁴  Pandian Arjun²  Changsik Song³ 

[1] Center of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India$$;Centre for Advanced Studies in Botany, Fungal Biotechnology, Natural Products and Plant Tissue Culture Lab, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India$$;Department of Chemistry, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Republic of Korea$$;Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India$$

关键词: Coumarin;    1;    2;    3-triazole;    anti-microbial;    molecular docking and ADMET.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A series of triazolylcoumarins was synthesized by the cycloaddition of acetylenic derivatives to azide in the presence of Cu(I) catalyst at room temperature. All the synthesized compounds were evaluated for their anti-microbial activity against Gram-positive (B. subtilis and S. aureus), Gram-negative bacteria (K. pneumonia and P. vulgaris) and human pathogenic fungi (C. tropicalis and C. krusei), with tetracycline and fluconazole as standards for anti-microbial and anti-fungal activity. Triazolylcoumarins exhibit anti-microbial activity against all the tested pathogens, which is further supported by molecular docking studies.

【 授权许可】

Unknown