Synthesis of N-substituted phthalimidoalkyl 1H-1,2,3-triazoles: a molecular diversity combining click chemistry and ultrasound irradiation

Journal of the Brazilian Chemical Society

Camara, Celso A.¹  Silva, Mauro G. da¹  Barbosa, Fernanda C. G.¹  Valença, Wagner O.¹  Universidade Federal Rural de Pernambuco, Recife, Brazil¹  Oliveira, Ronaldo N. de¹  Silva, Moara T. da¹ 

关键词: 1;    2;    3-triazole;    phthalimide;    ultrasound;    copper-catalyst;    click chemistry;   

DOI  :  

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A series of 1,2,3-triazole derivatives was synthesized from N-phthalimidoalkyl-azides (A1 -A4) and alkynes (a-e) under ultrasound irradiation in the presence of CuI, Et3N and DMF as solvent. The present protocol afforded 18 new 1,2,3-triazoles (1-4) in good-to-excellent yields (67-98%).

【 授权许可】

Unknown