Facile green synthesis and potent antimicrobial efficacy of 𝛽-aminoheteronapthol via tailored Betti’s protocol and their bis-aryl hydrazone click products

Journal of Chemical Sciences

J S Meshram¹  M D Shanti¹  K M Khandarkar1 2¹  M Ahmed² 

[1] Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India$$;Department of Chemistry, Government Polytechnic Sakoli, Bhandara 441 802, India$$

关键词: Green synthesis;    zeolite catalyst;    click reaction;    antimicrobial efficacy.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A series of novel Mannich base and their hydrazone derivatives were synthesized by highly resourceful, chic, simple and green technique with exceptionally facile reaction conditions of one-pot, three component reaction with an array of biologically and pharmaceutically active novel heterocycles. The protocol offers a valuable alternative to known methods and will find applications in the field of green synthesis and antimicrobial study against pathogenic microbes, supporting the development of bioinformatical database of novel and derelict heterocycles. These data indicate their potential to become antifungal agents. The novel products were established by elemental, IR, mass spectroscopic and NMR analysis. The environmental advantages of the method include short reaction time, excellent yield, easy work-up, absence of extraction and chromatographic purification steps.

【 授权许可】

Unknown