Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles

Molecules

Hyunje Woo¹  Hyuntae Kang¹  Aram Kim¹  Seongwan Jang¹  Ji Chan Park¹  Sungkyun Park¹  Byeong-Su Kim¹  Hyunjoon Song¹ 

[1] ¹Department of Chemistry, Chemistry Institute for Functional Materials, Pusan National University, Busan 609-735, Korea

关键词: copper oxide;    nanocatalyst;    heterogeneous;    hybrid;    click reaction;   

DOI  :  10.3390/molecules171113235

来源: mdpi

【 摘 要 】

Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block copolymer (DHBC) nanoreactors and ZnO–CuO hybrid NPs were synthesized. Non-conventional energy sources such as microwaves and ultrasound were also applied to these click reactions, and good catalytic activity with high regioselectivity was observed. CuO hollow NPs on acetylene black can be recycled nine times without any loss of activity, and water-soluble DHBC nanoreactors have been developed for an environmentally friendly process.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.