Biohybrid -Se-S- Coupling Reactions of an Amino AcidDerived Seleninate

Molecules

Mohannad Abdo¹  Zhexun Sun¹ 

[1] Department of Chemistry & Chemical Biology, Rutgers, the State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA

关键词: click reaction;    biomimetic;    seleninic acid;    thiol;   

DOI  :  10.3390/molecules18021963

来源: mdpi

【 摘 要 】

We describe the synthesis of the N-(2-seleninatoethyl) amide of N-Boc-phenylalanine, serving here as a peptide model, and its reductive coupling reactions under mild conditions with unprotected thiouridine and glutathione. Selenosulfide products such as these comprise reversibly conjugated bio-components, and can potentially find uses as probes of biological function, such as enzyme inhibitors, delivery systems, or structural mimics.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.