Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2𝐻)-yl)acetamide-based azetidinone derivatives as potent antibacterial and antifungal agents

Journal of Chemical Sciences

Shiv Kumar1³  Sushma Drabu¹  Nitin Kumar²  Md Akram Minhaj³ 

[1] Maharaja Surajmal Institute of Pharmacy, Janak Puri, New Delhi 110 058, India$$;Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut 250 005, India$$;Division of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering and Technology, Knowledge Park-I, Greater Noida 201 308, India$$

关键词: Quinoxaline;    azetidinone;    antibacterial;    antifungal.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Twelve compounds belonging to series N-[3-chloro-2-oxo-4-(substituted)phenylazetidin-1-yl]-2-(3-methyl-2-oxoquinoxalin-1(2𝐻)-yl)acetamide (5a-l) were synthesized. These compounds were evaluated for their in vitro antibacterial against E. coli, S. aureus, K. pneumoniae, P. aeruginosa and antifungal activity against C. albicans, A. niger and A. flavus by cup-plate method. Structures of all the newly synthesized compounds were confirmed by their spectral data interpretation. Compound 5g having 𝑝-dimethylaminophenyl group on 4-position of azetidinone ring attached to N-atom of acetamido group on 1-position of 3-methyl-1𝐻-quinoxaline-2-one, was found to be active against all the bacterial and fungal strains under investigation.

【 授权许可】

Unknown