Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice

Oriental Pharmacy and Experimental Medicine

Anandrao R. Kulkarni²  B. S. Thippeswami²  Kuntal Ganguly²  Ashok D. Taranalli¹  Rakesh Singh²  N. V. Jagadeesh² 

[1] KLE University’s College of Pharmacy$$;SET’s College of Pharmacy$$

关键词: Chromosomal aberration;   

DOI  :  10.1007/s13596-011-0023-5

学科分类：药学

来源: Springer

【 摘 要 】

This study was performed to determine whether Boswellic acid suppresses genotoxicity induced by cyclophosphamide in mice. Genotoxicity was induced by the administration of cyclophosphamide (50 mg/kg) in swiss albino mice and was measured by counting the number of micronuclei and observing chromosomal aberration. In test group Boswellic acid was given in the dose of 200 mg/kg and various chromosomal aberration and formation of micronuclei were observed. Boswellic acid in dose of 200 mg/kg significantly (P < 0.001) inhibited the cyclophosphamide induced micronucleus formation and also significantly (P < 0.001) inhibited chromosomal aberrations in mice. Whereas Boswellic acid alone did not either induce formation of micronuclei or chromosomal aberration in mice. Boswellic acid itself doesn’t have any genotoxic effect and suppresses genotoxicity induced by cyclophosphamide.

【 授权许可】

Unknown