The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

Cellular & Molecular Biology Letters

Vladimir V. Kazbanov³  Svetlana G. Paschkevich³  Andrey A. Denisov³  Alexey V. Kletskov⁴  Maria Bryszewska¹  Dmitri O. Lapotko²  Vladimir A. Kulchitsky³  Dzmitry Shcharbin⁵  Sergey K. Petkevich⁴  Vladimir I. Potkin⁴  Tatiana A. Gurinovich³ 

[1]Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland$$

[2]Department of Biochemistry and Cell Biology, Rice University, Houston, USA$$

[3]Institute of Physiology of National Academy of Sciences of Belarus, Minsk, Belarus$$

[4]Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus$$

[5]Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus, Minsk, Belarus$$Institute of Biophysics and Cell Engineering of NASB, Minsk, Belarus$$

关键词: Hypoxia;    Dendrimer;    Brain slices;    Postsynaptic potential;    Antitumor effects;    Heterocycles;    Isoxazoles;   

DOI  :  10.2478/s11658-014-0193-5

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.

【 授权许可】

Unknown